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To our knowledge, the only publications presenting an analysis of ca 2 i transient during microtubule alteration in adult cardiac myocytes are our recent report, in which an increase in ca 2 i transient after longer colchicine treatment was demonstrated, 18 and one by howarth et al, 19 who showed a decrease in ca 2 i transient after microtubule stabilization with taxol, suggesting that microtubules may be important regulators of ca 2 handling in the heart.

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May prescribe colchicine or nsaids to get rid of the pain and inflammation and put you on long term uric acid management .

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As soon as i feel the gout coming on you know after a couple of attacks i take 2 tiny colchicine tablets every two hour and stop after four hours and chug a lot of water.

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Low doses of colchicine are usually well tolerated but higher doses can lead to some side effects like nausea, vomiting and diarrhea.

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Inhibition of both cyp3a4 and p-gp by dual inhibitors such as clarithromycin has been reported to produce life-threatening or fatal colchicine toxicity due to significant increases in systemic colchicines levels.

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